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You can just sit tight trying to survice and try to open more sister hearts. Eventually the brothers will let you know what to do
Yeah I finished the parasites a while ago and was basically waiting. Well thanks Throdax, I'll just grow the garden next to The Wall for a bit longer (can't remember the name but certainly the best

). I sort of assumed that all I had left was to collect 21 hearts and ascend
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dude how did u manage to xD i'm almost in cycle 25 and can't kill worm yet
Oh... I found Worm was the easiest to kill... I had a lot of violet, emerald and crimson nerva. I also filled my hearts to 100% with crimson and gold and put some azure in to run faster. Not sure if the crimson works when you use glyphs and the gold may indeed do nothing either. I find when I fill my hearts with gold I seem to get lucky but it may be psychological... Anyway simply enter his realm, run up to the first predator and put a web glyph on it (before it gets eaten). The glyph costs ten nerva per use, I didn't "charge it" or anything, I've never noticed any difference

. Worm will always eat this one when you enter his realm. Wait until he finishes eating, gets hit with the glyph and re-enter the void. Go straight back into his realm and repeat. Took a while, he take about 30ish web glyphs. Still it took less than a cycle. I used violet first, then emerald then crimson nerva for the glyph. I guess any colour would do really, I just had lots of those.