Boris Vorontsov's ENBSeries DirectX injector is pretty amazing, and I'm surprised no one has posted about using it with Pathologic yet. So I set up my own custom ini configuration for Pathologic, based on the Half Life 2 one. See the results for yourself!
Video here, because why not:
http://www.youtube.com/watch?v=pFpCuR0QilE
It's got some pretty big issues that can (I think) only be fixed by someone with access to the original source. Ambient Occlusion showing over the interface may not sound like much, but it makes some parts of the text really hard to read. Maybe if enough of us send the developer mail about it he'd decide to make a custom version?
Here's the download:
https://dl.dropbox.com/u/17070747/Path/ ... ic_ENB.zip. Just extract and place in the same directory as Pathologic's bin directory. Using it with the 1080p mod is recommended! Note: requires a pretty high end computer to run nicely. If you can run The Void maxed out (No AA) at above 200fps you should be fine.