Thanks! That was a pretty insightful reply
I also understood the point being made: "This is only a game, and real life is much more important." It's quite a good thing to remember, but I think most people are quite aware of it - At least, I hope so!
One of the things that I thought was so good about Pathologic was the way that I could identify with the feelings of the character (in this case, Dankowsky). He was skeptical, confused, shocked and surprised by the strange world he found himself in. So was I. At the end, when he met the two children, he was incredibly angry at this idea of being a 'puppet.' He didn't want to believe it. I felt the same way. It was a natural reaction, and the game did a great job of making me feel the same way as Dankowsky did!
So over time, I've thought about the ending a bit more, and come to terms with it. I would prefer a different ending, but there it is. Besides, there are still some possibilities:
1. The children were lying. They did not create the town. Why should I believe them?
2. The children didn't create the town or the characters, but they *did* create the disease.
3. The children were telling the truth. They created everything, including the three heroes.
Relating this (option number 3) to the 'real world': We don't know for sure why *we* are alive. We have theories and scientific evidence about evolution and the creation of matter, but we can't explain everything... What is life, really? What is consciousness? Why am *I* a conscious being? How did the universe come into existence? And what is the universe really?
For all we know, we could be playthings for a couple of kids playing god
I'd be interested to read some more from Nikolai Dybowskiy - Are his speeches available anywhere online in printed form (so I can Babelfish 'em)?
One more thing I wanted to say:
I have viewed games as an art-form alongside movies and books for a long time. I'm pleased that they have become more popular over the last few years and people are taking them more seriously. But the level of writing and storytelling is still generally about the same as a regular popcorn action movie. There's rarely anything to rival great literature.
Pathologic *definitely* has the best told story I've experienced in a computer game, and playing it was really an experience that was closer to immersing myself in a great novel. I think games have a lot more possibilities to offer than any other art-form, because of the element of interaction and the ability to get closely involved with multiple characters within the story (Pathologic, with its three protagonists and their seperate viewpoints, is a great example of this). So you guys are definitely on the right track!
It's just a pity that as technology and game engines get more advanced, they're still generally being used to develop... mindless 3D shooters!

The upcoming game, 'Crysis', for instance, features accurate cycles of the sun, perfect shadows, perfectly plotted stars in the sky... But who's really going to notice all that when they're just mowing down as many enemy soldiers as they can? What a waste!
(Anyway, I've talked way too much here! I'll stop now...)